vaccine response assessment
Laboratory evaluation of antibody production following vaccination to determine immune system function.
Full Definition
A diagnostic approach used to evaluate humoral immune function by measuring antibody responses to specific vaccines, both protein and polysaccharide antigens. This assessment typically includes pre- and post-vaccination antibody titers to vaccines such as tetanus, diphtheria, pneumococcus, and Haemophilus influenzae type b. The evaluation helps distinguish between primary immunodeficiencies affecting antibody production and normal immune function. Response criteria vary by vaccine type and patient age, with polysaccharide vaccine responses being particularly important for assessing specific antibody deficiencies. Poor vaccine responses may indicate underlying immunodeficiency requiring further investigation.
Usage
Usage note: Distinguish from routine vaccine monitoring; emphasizes diagnostic immune evaluation.
In Context
- "Vaccine response assessment revealed inadequate antibody production despite normal immunoglobulin levels." — Immunodeficiency workup report
- "The protocol included vaccine response assessment using pneumococcal polysaccharide vaccine." — Clinical research methodology