Intermediate
Technical
In the Industry Vocabulary Test
Burkitt lymphoma
Pronunciation: BURR-kit
An aggressive B-cell non-Hodgkin lymphoma characterized by rapid growth and specific chromosomal translocations.
Full Definition
Burkitt lymphoma is a highly aggressive B-cell non-Hodgkin lymphoma that represents one of the fastest-growing human tumors. It is characterized by the translocation of the MYC gene, most commonly t(8;14). Three variants exist: endemic (African), sporadic, and immunodeficiency-associated. The tumor typically presents in extranodal sites and requires intensive chemotherapy protocols. It is named after Denis Burkitt, who first described the African form in 1958.
Usage
Usage note: Capitalize 'Burkitt' as it is an eponym. Distinguish from 'Burkitt-like' lymphomas.
In Context
- "The biopsy confirmed Burkitt lymphoma with typical starry-sky morphology." — Pathology report
- "Burkitt lymphoma requires urgent initiation of intensive chemotherapy." — Treatment plan
Also known as
BL
Don't confuse with
Burkitt-like lymphoma
large B-cell lymphoma