CHOP Protocol
Also written as: CHOP — Cyclophosphamide, Hydroxydaunorubicin, Oncovin, Prednisone
A chemotherapy regimen using cyclophosphamide, doxorubicin (hydroxydaunorubicin), vincristine (Oncovin), and prednisone for treating pediatric lymphomas.
Full Definition
The CHOP protocol is a four-drug chemotherapy combination widely used in pediatric oncology for treating non-Hodgkin lymphomas and some other hematologic malignancies. The regimen consists of cyclophosphamide, doxorubicin (historically called hydroxydaunorubicin), vincristine (brand name Oncovin), and prednisone. Multiple variations exist, including R-CHOP which adds rituximab. Editors should note that CHOP is always capitalized and refers specifically to this drug combination, not to the Children's Hospital of Philadelphia.
Usage
Usage note: Always capitalize. Do not confuse with the Children's Hospital of Philadelphia, also abbreviated CHOP.
In Context
- "The patient received six cycles of CHOP protocol with excellent response." — Treatment summary
- "Dose modifications to the CHOP regimen were necessary due to cardiac toxicity." — Clinical note