dose intensity
The amount of chemotherapy delivered per unit of time, typically expressed as mg/m²/week.
Full Definition
Dose intensity refers to the amount of chemotherapy administered over a specific time period, usually calculated as the dose per unit body surface area per week (mg/m²/week). This concept is fundamental in pediatric oncology as it directly correlates with treatment efficacy and toxicity. Maintaining optimal dose intensity requires careful balance between maximum anti-tumor effect and acceptable toxicity, particularly challenging in children whose organ systems are still developing. Dose intensity can be compromised by treatment delays, dose reductions, or omitted cycles, potentially impacting cure rates. Many pediatric protocols specify minimum acceptable dose intensity levels and provide guidelines for dose modifications.
Usage
Usage note: Always specify the time unit and include body surface area normalization when reporting dose intensity calculations.
In Context
- "The protocol maintains high dose intensity during the critical induction phase." — Protocol development document
- "Dose intensity was reduced by 25% due to persistent grade 3 toxicity." — Treatment modification note