DIPG
Pronunciation: DIP-jee
Also written as: DIPG — Diffuse Intrinsic Pontine Glioma
An aggressive brainstem tumor with poor prognosis, typically presenting with cranial nerve palsies and ataxia in school-age children.
Full Definition
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive brain tumor that arises in the pons and accounts for 80% of pediatric brainstem gliomas. It primarily affects children between 4-9 years of age and is characterized by rapid onset of symptoms including cranial nerve palsies, ataxia, and pyramidal tract signs. The tumor is diagnosed based on characteristic MRI findings without the need for biopsy due to its location and typical presentation. DIPG has a universally poor prognosis with median survival of less than one year. Standard treatment consists of palliative radiation therapy, as surgical resection is not feasible due to the critical location within the brainstem.
Usage
Usage note: Recently reclassified as diffuse midline glioma in WHO classification; prognosis remains uniformly poor.
In Context
- "The diagnosis of DIPG was made based on characteristic MRI findings without tissue confirmation." — Neuro-oncology consultation
- "Palliative radiation therapy was initiated for the patient with newly diagnosed DIPG." — Treatment planning note