intensification therapy
A treatment phase using high-dose chemotherapy to eliminate residual cancer cells after achieving initial remission.
Full Definition
Intensification therapy, also known as consolidation therapy, is administered after successful induction treatment to eliminate minimal residual disease that may persist despite achieving morphologic remission. This phase typically involves dose-intense chemotherapy regimens that may include different drug combinations than those used in induction. In pediatric oncology, intensification protocols are carefully timed and may include high-dose chemotherapy with stem cell rescue for certain high-risk malignancies. The duration and intensity vary significantly based on cancer type, risk stratification, and patient tolerance.
Usage
Usage note: Often used interchangeably with 'consolidation therapy' though some protocols distinguish between these phases.
In Context
- "The patient is scheduled to begin intensification therapy following confirmation of remission status." — Treatment plan documentation
- "Monitor closely for toxicity during the intensification phase due to cumulative drug exposure." — Clinical protocol guidelines