MKI
Pronunciation: M-K-I
Also written as: MKI — Mitosis-Karyorrhexis Index
Histologic measure of cell division and death rates used in neuroblastoma prognostic assessment.
Full Definition
The Mitosis-Karyorrhexis Index (MKI) is a quantitative histologic parameter that measures the rate of cell division and nuclear degeneration within neuroblastoma tumors. MKI is calculated by counting mitotic figures and karyorrhectic nuclei per 5,000 tumor cells and is categorized as low (<100/5000 cells), intermediate (100-200/5000 cells), or high (>200/5000 cells). This index serves as an important prognostic factor in the International Neuroblastoma Pathology Classification, with higher MKI values generally associated with more aggressive tumor behavior and poorer outcomes. MKI assessment requires standardized counting methodology and experienced pediatric pathology interpretation to ensure accuracy and reproducibility.
Usage
Usage note: Specify counting methodology and classification category; critical for prognostic assessment.
In Context
- "Histologic review revealed a high MKI of 180 per 5,000 cells, indicating aggressive tumor behavior." — Pathology consultation
- "The favorable histology classification was supported by a low MKI and abundant Schwannian stroma." — Prognostic assessment