Schwannian stroma
Pronunciation: SHWAN-ee-an STRO-ma
Supportive tissue component in neuroblastoma tumors derived from Schwann cells, indicating differentiation.
Full Definition
Schwannian stroma refers to the supportive tissue matrix composed of Schwann cells and their associated extracellular components that can be present in varying amounts within neuroblastoma tumors. The quantity and distribution of Schwannian stroma is an important histologic feature used in tumor classification, with categories including stroma-poor, stroma-rich, and nodular patterns. Tumors with abundant Schwannian stroma generally have better prognosis than stroma-poor neuroblastomas, as the presence of stromal elements indicates a degree of tumor maturation and differentiation. The assessment of Schwannian stroma content requires careful histologic evaluation and contributes to the overall International Neuroblastoma Pathology Classification system.
Usage
Usage note: Quantitative assessment affects tumor classification; distinguish from other stromal patterns.
In Context
- "Microscopic examination showed abundant Schwannian stroma with focal calcifications." — Histopathology report
- "The tumor was classified as stroma-rich based on the predominant Schwannian stroma content." — Pathologic diagnosis