shimmer cells
Histologic feature of neuroblastoma characterized by cells with abundant cytoplasm and peripheral chromatin.
Full Definition
Shimmer cells are a distinctive histologic feature observed in some neuroblastomas, characterized by large cells with abundant, faintly eosinophilic cytoplasm and peripheral displacement of nuclear chromatin, creating a characteristic 'shimmer' appearance under light microscopy. These cells represent a form of neuronal differentiation and their presence may indicate a more favorable prognosis compared to undifferentiated neuroblastomas. Shimmer cells are part of the histologic grading system used to assess tumor differentiation, along with other features such as mitosis-karyorrhexis index and overall cellular morphology. Their identification requires experienced pediatric pathology review and contributes to the overall histologic classification that influences treatment planning.
Usage
Usage note: Specific pathologic finding requiring expert interpretation; impacts histologic grading and prognosis.
In Context
- "Histologic examination revealed scattered shimmer cells consistent with differentiating neuroblastoma." — Pathology report
- "The presence of shimmer cells supported classification as intermediate-grade neuroblastoma." — Histologic grading assessment