vincristine
Pronunciation: vin-KRIS-teen
A chemotherapy drug derived from the periwinkle plant, commonly used in pediatric cancer protocols.
Full Definition
Vincristine is a vinca alkaloid chemotherapy agent derived from the Madagascar periwinkle plant (Catharanthus roseus). It works by disrupting microtubule formation during cell division, causing cell cycle arrest. Vincristine is a cornerstone of many pediatric cancer treatment protocols, particularly for ALL, lymphomas, brain tumors, and solid tumors. The drug is administered intravenously and has dose-limiting peripheral neuropathy as its primary toxicity. In pediatric patients, vincristine doses are often capped to reduce neurologic complications while maintaining efficacy.
Usage
Usage note: Often abbreviated as VCR; doses may be capped in pediatric protocols.
In Context
- "The ALL induction protocol includes vincristine 1.5 mg/m2 weekly for four doses." — Chemotherapy order
- "Monitor for vincristine-induced peripheral neuropathy at each visit." — Clinical care guideline