VOD
Also written as: VOD — Veno-Occlusive Disease
Veno-occlusive disease, a serious complication of high-dose chemotherapy affecting liver blood vessels.
Full Definition
Veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome, is a potentially life-threatening complication that can occur after high-dose chemotherapy, particularly in the setting of stem cell transplantation. VOD results from injury to hepatic sinusoidal endothelial cells and hepatocytes, leading to obstruction of hepatic venules and sinusoids. Clinical manifestations include hepatomegaly, right upper quadrant pain, ascites, weight gain, and elevated bilirubin levels. In pediatric oncology, VOD is most commonly associated with certain chemotherapeutic agents and conditioning regimens used before hematopoietic stem cell transplantation. Early recognition and prompt treatment with defibrotide can be life-saving.
Usage
Usage note: Specify severity grade (mild, moderate, severe) and include serum bilirubin levels when documenting VOD.
In Context
- "The patient developed VOD with rising bilirubin and hepatomegaly on day +12 post-transplant." — Transplant complication report
- "Monitor closely for signs of VOD during the conditioning regimen." — Pre-transplant care plan