Langerhans cell histiocytosis
Pronunciation: LANG-er-hans cell his-tee-oh-sy-TOH-sis
Also written as: LCH — Langerhans cell histiocytosis
A disorder characterized by clonal proliferation of abnormal Langerhans cells affecting multiple organ systems.
Full Definition
Langerhans cell histiocytosis (LCH) is a rare disorder involving the clonal proliferation and accumulation of abnormal Langerhans cells. In pediatric radiology, LCH presents with characteristic punched-out lytic bone lesions, often with a beveled edge appearance on skull radiographs. The condition can affect single or multiple organ systems, including bones, skin, lungs, and the central nervous system. Imaging findings vary by location but commonly include well-defined osteolytic lesions and characteristic patterns of organ involvement.
Usage
Usage note: Emphasize the characteristic appearance of bone lesions and multi-system involvement.
In Context
- "Skull radiograph showed multiple punched-out lesions consistent with Langerhans cell histiocytosis." — Pediatric oncology workup