Psychiatric Research Glossary

The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision - the primary classification sys...

The time interval between the onset of psychotic symptoms and the initiation of adequate antipsychotic treatment.

Real-time data collection method capturing participants' experiences and behaviors in their natural environment.

The extent to which research findings can be generalized to real-world clinical settings and everyday functioning.

The pattern and timing of symptom improvement or side effect development during psychiatric treatment.

Statistical strategy that orders multiple endpoints to control Type I error while preserving study power.

Clinical trial strategy that selects participants based on characteristics that increase likelihood of treatment respons...

Study population selected to increase likelihood of demonstrating treatment effects through specific inclusion criteria.

A clinical trial design approach that selects participants likely to respond to treatment or experience the outcome of i...

Movement disorders caused by antipsychotic medications affecting the brain's motor control systems.

The initial occurrence of psychotic symptoms in an individual, representing a critical period for early intervention and...

Statistical phenomenon where assessment scores cluster at the lowest possible value, limiting ability to measure improve...

Reduction in ability to perform daily activities, work, or social functions due to psychiatric symptoms.

Achievement of normal or near-normal daily functioning despite possible persistence of some psychiatric symptoms.

A numeric scale used to rate overall psychological, social, and occupational functioning in psychiatric patients.

The 17-item version of the Hamilton Depression Rating Scale, a clinician-rated assessment tool measuring depression seve...

A clinician-administered assessment tool measuring depression severity, commonly abbreviated as HAM-D or HDRS in psychia...

An ethics committee that reviews and approves psychiatric research involving human subjects, ensuring participant safety...

An analysis method in psychiatric trials that includes all randomized participants in their originally assigned treatmen...

The degree of agreement between different raters when scoring the same assessment or rating scale.

A clinical study designed, conducted, and sponsored by academic investigators rather than pharmaceutical companies.

A statistical imputation method for handling missing data by using a participant's last recorded value.

A 10-item clinician-rated scale used to assess the severity of depressive symptoms in psychiatric research.

The Montgomery-Åsberg Depression Rating Scale - Self-assessment version, a patient-rated scale for measuring depressive...