diminished ovarian reserve
Also written as: DOR — Diminished Ovarian Reserve
Condition characterized by reduced quantity or quality of eggs relative to chronological age.
Full Definition
Diminished ovarian reserve (DOR) refers to a reduction in the quantity and/or quality of oocytes and is associated with decreased fertility potential. This condition can occur naturally with aging or prematurely due to genetic factors, medical treatments (such as chemotherapy), surgical interventions, or unknown causes. Diagnosis typically involves assessment of anti-Müllerian hormone levels, antral follicle count on ultrasound, and sometimes day 3 follicle-stimulating hormone levels. Women with DOR may experience reduced response to ovarian stimulation, requiring modified treatment protocols and often having lower success rates with assisted reproductive technology. Early diagnosis allows for appropriate counseling and treatment planning, including consideration of donor eggs in severe cases.
Usage
Usage note: Distinguish from primary ovarian insufficiency, which involves hormonal deficiency.
In Context
- "The diagnosis of diminished ovarian reserve was based on low AMH levels and poor response to stimulation." — Medical record
- "Patients with diminished ovarian reserve require counseling about realistic treatment expectations." — Clinical guideline