poor responder
A patient who produces fewer follicles and eggs than expected during ovarian stimulation, despite adequate medication dosing.
Full Definition
A poor responder is a patient who demonstrates a suboptimal response to standard ovarian stimulation protocols, characterized by development of few mature follicles and retrieval of limited numbers of eggs. Various criteria exist for defining poor response, but commonly include retrieval of fewer than 4 eggs, presence of fewer than 5 antral follicles, or requiring high gonadotropin doses. Poor response may be related to advanced maternal age, diminished ovarian reserve, genetic factors, or previous ovarian surgery. Management often requires protocol modifications, higher medication doses, or consideration of alternative approaches such as minimal stimulation or donor eggs.
Usage
Usage note: Specify the criteria used to define poor response and consider alternative strategies.
In Context
- "The patient was classified as a poor responder with only 3 eggs retrieved despite maximum stimulation." — IVF cycle summary
- "Poor responder protocols may include higher starting doses and adjuvant treatments." — Treatment planning discussion