poor responder syndrome
Condition where patients show inadequate ovarian response to standard gonadotropin stimulation protocols.
Full Definition
Poor responder syndrome describes a clinical condition characterized by reduced ovarian response to controlled ovarian hyperstimulation, typically defined by low numbers of developing follicles, poor estradiol rise, or low egg retrieval numbers. The Bologna criteria established standardized definitions including advanced maternal age, previous poor response, or abnormal ovarian reserve tests. Poor responders often require modified treatment approaches such as higher gonadotropin doses, alternative stimulation protocols, or adjuvant therapies. This condition is associated with decreased pregnancy rates and represents a significant challenge in assisted reproductive technology. Treatment strategies may include minimal stimulation, natural cycle IVF, or consideration of donor eggs.
Usage
Usage note: Often abbreviated as POR in clinical documentation
In Context
- "The patient met Bologna criteria for poor responder syndrome based on previous cycle outcome." — Treatment planning note
- "Alternative protocols were considered due to poor responder syndrome diagnosis." — Clinical consultation