Professional
Technical
IVT
PGT-M
Also written as: PGT-M — Preimplantation Genetic Testing for Monogenic Disorders
Preimplantation genetic testing for monogenic disorders, testing embryos for specific inherited conditions.
Full Definition
Preimplantation genetic testing for monogenic disorders (PGT-M) is used to test embryos for specific single-gene disorders when one or both parents are known carriers or affected by a genetic condition. Unlike PGT-A which screens for chromosomal abnormalities, PGT-M targets specific mutations such as cystic fibrosis, sickle cell disease, or Huntington's disease. The test requires family-specific probe development and is highly accurate for the targeted condition.
Usage
Usage note: Hyphenate when used as an adjective. Formerly called PGD.
In Context
- "The couple elected PGT-M testing to avoid transmitting the BRCA1 mutation to their offspring." — Genetic counseling report
- "PGT-M requires extensive family history and genetic testing before cycle initiation." — Clinical protocol document
Also known as
preimplantation genetic diagnosis
PGD
Don't confuse with
PGT-A
PGT-SR