PGT-SR
Also written as: PGT-SR — preimplantation genetic testing for structural rearrangements
Preimplantation genetic testing for structural chromosomal rearrangements to identify embryos with balanced chromosome complements.
Full Definition
Preimplantation genetic testing for structural rearrangements (PGT-SR) is a specialized form of genetic testing performed on embryo biopsies to identify those with normal or balanced chromosome arrangements in couples where one partner carries a structural chromosomal abnormality. This testing is particularly indicated for carriers of balanced translocations, inversions, or other structural rearrangements who are at risk of producing embryos with unbalanced chromosomes. PGT-SR uses advanced molecular techniques to detect the specific chromosomal imbalances associated with each unique rearrangement, allowing for the selection and transfer of genetically balanced embryos.
Usage
Usage note: Part of the updated PGT nomenclature; previously called PGD for translocations.
In Context
- "PGT-SR testing identified three embryos with balanced chromosome complements suitable for transfer." — Genetic testing results
- "The genetic counselor explained that PGT-SR would specifically test for the chromosomal imbalances related to the patient's translocation." — Pre-procedure counseling