lactate clearance
Percentage decrease in serum lactate levels over time, used as a marker of resuscitation adequacy and prognosis in shock.
Full Definition
Lactate clearance refers to the percentage reduction in serum lactate concentration over a specified time period, typically calculated as (initial lactate - subsequent lactate)/initial lactate × 100. It serves as an important marker of tissue perfusion and metabolic recovery during resuscitation of patients in shock. A lactate clearance of ≥10% at 2 hours or ≥20% at 6 hours is associated with improved outcomes. Failure to clear lactate may indicate ongoing tissue hypoperfusion, inadequate resuscitation, or underlying metabolic dysfunction requiring further intervention.
Usage
Usage note: Express as percentage with timeframe; avoid confusion with renal lactate clearance.
In Context
- "Poor lactate clearance at 6 hours prompted reassessment of resuscitation strategy." — ICU progress note
- "The patient demonstrated excellent lactate clearance following fluid resuscitation." — Emergency medicine documentation