clear cell renal carcinoma
Also written as: ccRCC — clear cell renal cell carcinoma
Most common subtype of kidney cancer characterized by clear cytoplasm and typically more aggressive behavior.
Full Definition
Clear cell renal carcinoma (ccRCC) is the most prevalent subtype of renal cell carcinoma, accounting for approximately 75-80% of all kidney cancers. This tumor type is characterized by cells with clear, glycogen-rich cytoplasm and a distinctive vascular pattern on microscopic examination. ccRCC typically arises from the proximal tubule epithelium and is associated with VHL gene alterations in many cases. The tumor tends to be more aggressive than other RCC subtypes, with higher potential for metastasis, but also shows better response to targeted therapies such as VEGF inhibitors and immune checkpoint inhibitors. The clear cell appearance results from intracytoplasmic accumulation of lipids and glycogen.
Usage
Usage note: Hyphenate 'clear cell' when used as a compound modifier. ccRCC is the standard abbreviation.
In Context
- "The pathology confirmed clear cell renal carcinoma with sarcomatoid features." — Pathology report
- "Clear cell renal carcinoma typically shows enhancement on contrast-enhanced CT imaging." — Radiology teaching