Professional
Technical
IVT
teratoma with malignant transformation
A germ cell tumor containing mature tissues that has undergone malignant change to form secondary carcinomas or sarcomas.
Full Definition
Teratoma with malignant transformation represents a complex germ cell tumor where mature teratomatous elements undergo secondary malignant change, developing into various carcinomas or sarcomas. This complication can occur in primary testicular tumors or metastatic sites, particularly retroperitoneal masses. These transformed elements are typically chemotherapy-resistant and require complete surgical resection. The presence of malignant transformation significantly impacts prognosis and treatment planning.
Usage
Usage note: Requires complete phrase for clarity; avoid abbreviating as 'TMT' which has other medical meanings.
In Context
- "Complete surgical resection was required due to teratoma with malignant transformation identified in the retroperitoneal mass." — Multidisciplinary tumor board discussion
- "The pathology revealed adenocarcinoma arising within teratoma with malignant transformation." — Pathology consultation report
Also known as
teratoma with somatic malignancy
malignant transformation in teratoma
Contrasted with
mature teratoma
immature teratoma
Don't confuse with
immature teratoma
embryonal carcinoma
teratocarcinoma