CEC
Also written as: CEC — Clinical Events Committee
An independent committee of clinical experts who review and classify clinical events in a standardized manner to ensure consistent endpoint adjudication.
Full Definition
A Clinical Events Committee (CEC) or Clinical Endpoint Committee serves as an independent body of medical experts who review clinical events reported during clinical trials to determine whether they meet predefined endpoint criteria. Committee members are blinded to treatment assignment and use standardized definitions and protocols to classify events such as myocardial infarction, stroke, or cardiovascular death. In cardiovascular research, CECs are essential for maintaining objectivity and consistency in endpoint determination, particularly for composite endpoints where multiple event types must be accurately classified.
Usage
Usage note: Distinguish from 'endpoint adjudication' which refers to the process rather than the committee itself.
In Context
- "All suspected cardiovascular events were adjudicated by a blinded CEC using standardized criteria." — Methods section
- "The CEC charter defined specific criteria for myocardial infarction based on universal definition guidelines." — Study protocol