tumor lysis syndrome
Also written as: TLS — Tumor Lysis Syndrome
Metabolic complication following rapid tumor cell death, occasionally seen after aggressive NET treatment.
Full Definition
Tumor lysis syndrome (TLS) is a potentially life-threatening oncologic emergency resulting from rapid breakdown of tumor cells, leading to release of intracellular contents into the circulation. While classically associated with hematologic malignancies, TLS can rarely occur in neuroendocrine tumors following aggressive treatments such as chemotherapy, targeted therapy, or hepatic embolization. The syndrome is characterized by hyperkalemia, hyperphosphatemia, hyperuricemia, and hypocalcemia, which can progress to acute kidney injury, cardiac arrhythmias, and seizures. In endocrine oncology, TLS risk is generally low but should be considered in patients with high tumor burden receiving systemic therapy.
Usage
Usage note: Uncommon in NETs but consider in high tumor burden cases receiving systemic therapy.
In Context
- "Laboratory monitoring was intensified to detect early signs of tumor lysis syndrome." — chemotherapy protocol
- "Allopurinol was administered prophylactically to prevent tumor lysis syndrome." — treatment plan