VIPoma
Pronunciation: VIP-oh-muh
Also written as: VIP — vasoactive intestinal peptide tumor
A rare functional neuroendocrine tumor secreting vasoactive intestinal peptide, causing watery diarrhea syndrome.
Full Definition
VIPomas are rare functional neuroendocrine tumors that secrete excessive vasoactive intestinal peptide (VIP), leading to the characteristic watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome, also known as Verner-Morrison syndrome. These tumors most commonly arise in the pancreas but can occur in other locations. The hallmark clinical presentation includes profuse watery diarrhea (often exceeding 3 liters daily), severe hypokalemia, and metabolic acidosis. Diagnosis requires demonstration of elevated plasma VIP levels in the setting of appropriate clinical symptoms. Treatment involves surgical resection when possible, with somatostatin analogs providing effective symptomatic control.
Usage
Usage note: VIP should be spelled in all capitals; distinguish from other causes of secretory diarrhea.
In Context
- "The patient's severe hypokalemia and watery diarrhea prompted evaluation for VIPoma." — Emergency department note
- "Plasma VIP levels of 850 pg/mL confirmed the suspected diagnosis of VIPoma." — Endocrinology consultation