IDH-wildtype
Also written as: IDH — Isocitrate Dehydrogenase
A molecular classification indicating absence of IDH mutations, associated with more aggressive glioma behavior.
Full Definition
IDH-wildtype refers to gliomas that lack mutations in the isocitrate dehydrogenase (IDH) genes, specifically IDH1 and IDH2. This molecular classification is fundamental to modern brain tumor diagnosis and has replaced many traditional histological categories. IDH-wildtype glioblastomas are associated with more aggressive behavior and poorer prognosis compared to IDH-mutant tumors. Editors must understand the diagnostic and prognostic implications of IDH status and ensure accurate reporting of this molecular marker in clinical and research contexts.
Usage
Usage note: Hyphenate 'IDH-wildtype' when used as adjective; distinguish clearly from IDH-mutant status.
In Context
- "The tumor was classified as IDH-wildtype glioblastoma with MGMT promoter unmethylated status." — Pathology report
- "IDH-wildtype astrocytomas in adults are now classified as glioblastoma regardless of histological grade." — Diagnostic classification update