Stevens-Johnson syndrome
Pronunciation: STEE-vens JOHN-son syndrome
Also written as: SJS — Stevens-Johnson syndrome
A severe mucocutaneous reaction characterized by widespread epidermal necrosis and detachment, often drug-induced and potentially life-threatening.
Full Definition
Stevens-Johnson syndrome (SJS) is a rare but serious mucocutaneous disorder representing the milder end of the SJS/toxic epidermal necrolysis spectrum, with less than 10% body surface area involvement. The condition typically begins with flu-like symptoms followed by painful mucosal erosions and a spreading erythematous rash that progresses to vesicles, bullae, and epidermal detachment. In children, SJS is most commonly triggered by medications such as sulfonamides, anticonvulsants, and NSAIDs. Early recognition and discontinuation of the offending agent are crucial for preventing progression to more severe disease.
Usage
Usage note: Always document the suspected triggering medication and percentage of body surface area affected.
In Context
- "The child developed Stevens-Johnson syndrome three days after starting trimethoprim-sulfamethoxazole." — Emergency department presentation
- "Immediate discontinuation of all medications was ordered upon suspicion of Stevens-Johnson syndrome." — Urgent care protocol