cytokine release syndrome
Pronunciation: SY-toh-kyne ree-LEES SIN-drome
Also written as: CRS — Cytokine Release Syndrome
A systemic inflammatory response characterized by fever and organ dysfunction, commonly associated with immunotherapies.
Full Definition
Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiorgan dysfunction caused by excessive release of pro-inflammatory cytokines. It is a common toxicity of CAR-T cell therapy and other immunotherapies, occurring when activated immune cells release large quantities of cytokines including interleukin-6, interferon-gamma, and tumor necrosis factor-alpha. Symptoms range from mild flu-like illness to severe multiorgan failure requiring intensive care. Treatment includes supportive care and targeted therapies like tocilizumab (anti-IL-6 receptor antibody).
Usage
Usage note: Do not hyphenate 'cytokine release' but may hyphenate when used as compound modifier.
In Context
- "Grade 2 cytokine release syndrome developed on day 3 after CAR-T cell infusion." — Progress note
- "Tocilizumab was administered for management of severe cytokine release syndrome." — Treatment record