GD2
Pronunciation: G-D-two
Cell surface ganglioside antigen highly expressed on neuroblastoma cells, target for immunotherapy.
Full Definition
GD2 is a disialoganglioside found on the cell surface that is highly expressed on neuroblastoma cells and serves as an important target for immunotherapy approaches. This antigen has limited expression on normal tissues, making it an attractive therapeutic target with reduced risk of autoimmune toxicity. Anti-GD2 monoclonal antibodies such as dinutuximab are now standard components of high-risk neuroblastoma treatment protocols. GD2-directed immunotherapy has significantly improved survival outcomes when combined with cytokines and isotretinoin in the maintenance phase of treatment. The antigen's consistent expression across neuroblastoma subtypes makes it valuable for both therapeutic targeting and diagnostic applications.
Usage
Usage note: Context determines whether referring to the antigen itself or GD2-directed therapy; specify when discussing immunotherapy.
In Context
- "Immunohistochemistry confirmed strong GD2 expression throughout the tumor specimen." — Pathology report
- "The patient experienced grade 2 neuropathic pain during GD2-directed immunotherapy." — Toxicity assessment