INRG
Also written as: INRG — International Neuroblastoma Risk Group
Global classification system for neuroblastoma risk stratification based on clinical and biological factors.
Full Definition
The International Neuroblastoma Risk Group (INRG) is a comprehensive classification system that stratifies neuroblastoma patients into risk categories based on age at diagnosis, histologic category, grade of tumor differentiation, MYCN amplification status, 11q aberration, and ploidy. The INRG system replaced older classification schemes by incorporating advances in tumor biology and genomics to better predict prognosis and guide treatment intensity. Patients are classified as very low risk, low risk, intermediate risk, or high risk, with corresponding treatment protocols ranging from observation to intensive multimodal therapy. The INRG classification has become the international standard for pediatric neuroblastoma risk assessment and clinical trial stratification.
Usage
Usage note: Distinguish from older INSS staging system; specify version when referencing classification criteria.
In Context
- "INRG classification placed the patient in the high-risk category based on age and MYCN amplification." — Risk stratification documentation
- "Treatment assignment followed INRG guidelines for intermediate-risk neuroblastoma." — Protocol selection justification