NSE
Also written as: NSE — Neuron-Specific Enolase
Serum biomarker elevated in neuroblastoma and other neuroendocrine tumors.
Full Definition
Neuron-Specific Enolase (NSE) is a glycolytic enzyme found primarily in neurons and neuroendocrine cells that serves as a serum biomarker for neuroblastoma and other neural crest tumors. Elevated NSE levels correlate with tumor burden and disease stage in neuroblastoma patients, making it useful for initial diagnosis, treatment monitoring, and surveillance. NSE levels typically decline with successful treatment and may rise with disease progression or recurrence. While not as specific as urinary catecholamine metabolites, NSE provides complementary information about tumor activity and is particularly valuable in MIBG-negative neuroblastomas.
Usage
Usage note: Report with reference ranges; may be elevated in other conditions including hemolysis.
In Context
- "Baseline NSE was significantly elevated at 250 ng/mL, consistent with high tumor burden." — Laboratory assessment
- "NSE levels normalized by the end of induction therapy, suggesting good treatment response." — Treatment monitoring report