osteosarcoma
Pronunciation: AH-stee-oh-sar-KOH-mah
A primary bone cancer that predominantly affects children and adolescents, most commonly occurring in the metaphyses of long bones.
Full Definition
Osteosarcoma is the most common primary bone malignancy in the pediatric population, typically arising in the metaphyseal region of long bones such as the distal femur and proximal tibia. It accounts for approximately 60% of all bone sarcomas in children and adolescents. The tumor is characterized by the production of osteoid or immature bone by malignant cells. Treatment typically involves neoadjuvant chemotherapy followed by surgical resection and adjuvant chemotherapy. The prognosis is generally favorable for localized disease, with 5-year survival rates exceeding 70%.
Usage
Usage note: Often confused with Ewing sarcoma in editorial contexts; ensure correct spelling of 'osteosarcoma' (not 'osteosarkoma').
In Context
- "The patient presented with osteosarcoma of the distal femur requiring neoadjuvant chemotherapy." — Oncology consultation note
- "Imaging revealed characteristic sunburst pattern consistent with osteosarcoma." — Radiology report