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extracapsular extension

Also written as: ECE — extracapsular extension

Tumor growth beyond the prostate capsule into surrounding tissues, indicating locally advanced disease.

Full Definition

Extracapsular extension (ECE) refers to the penetration of prostate cancer through the prostatic capsule into the periprostatic soft tissue. This finding indicates pT3a disease according to TNM staging and represents locally advanced prostate cancer. ECE can be detected preoperatively with multiparametric MRI or identified on final pathology after radical prostatectomy. The extent of extracapsular extension, whether focal or extensive, influences prognosis and treatment recommendations. Patients with ECE have higher risk of biochemical recurrence and may benefit from adjuvant radiation therapy.

Usage

Usage note: Often abbreviated as ECE. Distinguish from seminal vesicle invasion, which represents pT3b disease.

In Context

"Focal extracapsular extension was identified at the left posterolateral margin on final pathology." — Surgical pathology report
"The MRI suggested possible extracapsular extension, which was confirmed at radical prostatectomy." — Clinical assessment note

Also known as

ECE capsular penetration extraprostatic extension

Contrasted with

organ-confined disease intracapsular disease

Don't confuse with

seminal vesicle invasion perineural invasion

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