Oncology Informatics Glossary
100 terms total — 24 showing — Last updated 15 Sep 2026
COSMIC COSMIC
The Catalogue of Somatic Mutations in Cancer, a comprehensive database of cancer-associated genetic variants.
clinical data lake
Large-scale storage repository that holds vast amounts of structured and unstructured cancer-related data in its native...
clinical data management system
Software platform designed to collect, manage, and validate clinical trial data according to regulatory standards.
clinical data warehouse
A centralized repository that integrates clinical data from multiple healthcare systems and sources to support cancer re...
clinical decision support
Health information technology that provides clinicians with cancer-specific assessments and evidence-based recommendatio...
clinical trial matching
The process of systematically identifying and connecting cancer patients with appropriate research studies based on thei...
clinical variant classification
The systematic assignment of clinical significance levels to genetic variants based on evidence criteria.
CoC standards
Commission on Cancer accreditation standards for hospital cancer programs and registry operations.
companion diagnostic
An FDA-approved test required to identify patients eligible for specific targeted cancer therapies.
complete response
Disappearance of all detectable disease following cancer treatment, as defined by specific imaging and clinical criteria...
copy number variation
Genomic alterations involving the duplication or deletion of DNA segments in cancer cells.
COSMIC
The Catalogue of Somatic Mutations in Cancer, a comprehensive database of cancer-associated genetic variants.
CTCAE
Common Terminology Criteria for Adverse Events - NCI standard for grading adverse events in cancer clinical trials.
CTMS
Clinical Trial Management System used to manage the operational aspects of clinical trials including patient enrollment,...
DICOM
International standard for medical imaging data storage, transmission, and display, essential for oncology imaging workf...
disease-free survival
Time from treatment completion or surgical resection until cancer recurrence or death, commonly used in adjuvant therapy...
ECOG performance status
Standardized scale from 0-5 measuring a cancer patient's functional capacity and ability to perform daily activities.
eCRF
Electronic Case Report Form, a digital data collection instrument used in clinical trials to capture patient information...
ePRO
Electronic patient-reported outcome tools that capture symptoms, quality of life, and functional status directly from ca...
FAIR data principles
Guidelines for making scientific data Findable, Accessible, Interoperable, and Reusable, particularly important in oncol...
federated learning
Machine learning approach that enables model training across distributed datasets without centralizing patient data, imp...
genomic sequencing panel
Targeted genetic testing that analyzes multiple cancer-related genes simultaneously to guide precision oncology treatmen...
germline variant
A genetic variation present in inherited DNA from parents, found in all cells of the body.
HL7 FHIR
Health Level Seven Fast Healthcare Interoperability Resources - a standard for health information exchange in oncology s...
hotspot mutation
A genetic alteration occurring at a genomic position with high mutation frequency across multiple cancer types or patien...