Oncology Informatics Glossary
100 terms total — 24 showing — Last updated 15 Sep 2026
COSMIC COSMIC
The Catalogue of Somatic Mutations in Cancer, a comprehensive database of cancer-associated genetic variants.
ICD-O-3
International Classification of Diseases for Oncology, Third Edition - the standard for coding cancer diagnoses and morp...
immune checkpoint inhibitor
Therapeutic agents that block regulatory pathways preventing immune system activation against cancer cells.
immunotherapy response informatics
Computational framework for analyzing and predicting patient responses to cancer immunotherapy treatments using multi-om...
interoperability testing
Systematic validation that different oncology information systems can effectively exchange and use shared cancer data.
liquid biopsy
A blood-based test that detects circulating tumor cells or tumor-derived genetic material.
LOINC
Logical Observation Identifiers Names and Codes, a universal standard for identifying medical laboratory observations an...
mCODE
Minimal Common Oncology Data Elements - a FHIR-based standard for cancer data interoperability.
microsatellite instability
A molecular phenotype indicating defective DNA mismatch repair mechanisms in tumor cells.
molecular diagnostic report
A structured laboratory document detailing genetic, genomic, or proteomic test results used to guide cancer diagnosis, p...
molecular pathology report
Diagnostic document containing genomic testing results and molecular biomarker information for cancer treatment decision...
molecular residual disease
Submicroscopic cancer cells detectable only through highly sensitive molecular techniques after primary treatment.
molecular tumor board
Specialized multidisciplinary meeting focused on interpreting genomic testing results and selecting precision oncology t...
multiomic data integration
The computational process of combining genomic, transcriptomic, proteomic, and clinical data to create comprehensive pat...
NAACCR
North American Association of Central Cancer Registries - organization that sets cancer data collection standards.
NCCN Guidelines API
Application programming interface providing programmatic access to National Comprehensive Cancer Network treatment proto...
next-generation sequencing
High-throughput DNA sequencing technologies enabling rapid analysis of multiple genes or entire genomes simultaneously.
OMOP CDM
Observational Medical Outcomes Partnership Common Data Model, a standardized data structure for organizing healthcare da...
OncoKB
A precision oncology knowledge base that annotates cancer variants with clinical actionability levels.
oncology data warehouse
Centralized repository specifically designed to store, integrate, and analyze cancer-related clinical and research data...
ORIEN
A collaborative network enabling cancer centers to share genomic and clinical data for precision oncology research.
outcome adjudication
Systematic review and validation process to confirm clinical endpoints in oncology studies, ensuring consistent and accu...
overall survival
Time from treatment initiation or randomization until death from any cause, the gold standard endpoint in cancer clinica...
pathologic complete response
Absence of invasive cancer cells in surgical specimens following neoadjuvant therapy, indicating excellent treatment res...
patient-derived xenograft database
Repository containing characterized cancer models derived from patient tumors, used for drug testing and biomarker disco...