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Oncology Informatics Glossary

100 terms total — 24 showing — Last updated 15 Sep 2026

COSMIC COSMIC

Intermediate Technical IVT

The Catalogue of Somatic Mutations in Cancer, a comprehensive database of cancer-associated genetic variants.

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ICD-O-3

Advanced Technical IVT

International Classification of Diseases for Oncology, Third Edition - the standard for coding cancer diagnoses and morp...

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immune checkpoint inhibitor

Intermediate Technical IVT

Therapeutic agents that block regulatory pathways preventing immune system activation against cancer cells.

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immunotherapy response informatics

Professional Technical IVT

Computational framework for analyzing and predicting patient responses to cancer immunotherapy treatments using multi-om...

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interoperability testing

Professional Technical IVT

Systematic validation that different oncology information systems can effectively exchange and use shared cancer data.

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liquid biopsy

Intermediate Technical IVT

A blood-based test that detects circulating tumor cells or tumor-derived genetic material.

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LOINC

Professional Technical IVT

Logical Observation Identifiers Names and Codes, a universal standard for identifying medical laboratory observations an...

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mCODE

Professional Technical IVT

Minimal Common Oncology Data Elements - a FHIR-based standard for cancer data interoperability.

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microsatellite instability

Intermediate Technical IVT

A molecular phenotype indicating defective DNA mismatch repair mechanisms in tumor cells.

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molecular diagnostic report

Intermediate Technical IVT

A structured laboratory document detailing genetic, genomic, or proteomic test results used to guide cancer diagnosis, p...

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molecular pathology report

Advanced Technical IVT

Diagnostic document containing genomic testing results and molecular biomarker information for cancer treatment decision...

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molecular residual disease

Professional Technical IVT

Submicroscopic cancer cells detectable only through highly sensitive molecular techniques after primary treatment.

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molecular tumor board

Advanced Technical IVT

Specialized multidisciplinary meeting focused on interpreting genomic testing results and selecting precision oncology t...

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multiomic data integration

Advanced Technical IVT

The computational process of combining genomic, transcriptomic, proteomic, and clinical data to create comprehensive pat...

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NAACCR

Professional Technical IVT

North American Association of Central Cancer Registries - organization that sets cancer data collection standards.

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NCCN Guidelines API

Professional Technical IVT

Application programming interface providing programmatic access to National Comprehensive Cancer Network treatment proto...

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next-generation sequencing

Intermediate Technical IVT

High-throughput DNA sequencing technologies enabling rapid analysis of multiple genes or entire genomes simultaneously.

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OMOP CDM

Professional Technical IVT

Observational Medical Outcomes Partnership Common Data Model, a standardized data structure for organizing healthcare da...

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OncoKB

Professional Technical IVT

A precision oncology knowledge base that annotates cancer variants with clinical actionability levels.

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oncology data warehouse

Professional Technical IVT

Centralized repository specifically designed to store, integrate, and analyze cancer-related clinical and research data...

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ORIEN

Professional Technical IVT

A collaborative network enabling cancer centers to share genomic and clinical data for precision oncology research.

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outcome adjudication

Professional Technical IVT

Systematic review and validation process to confirm clinical endpoints in oncology studies, ensuring consistent and accu...

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overall survival

Intermediate Technical IVT

Time from treatment initiation or randomization until death from any cause, the gold standard endpoint in cancer clinica...

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pathologic complete response

Advanced Technical IVT

Absence of invasive cancer cells in surgical specimens following neoadjuvant therapy, indicating excellent treatment res...

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Repository containing characterized cancer models derived from patient tumors, used for drug testing and biomarker disco...

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