Psychiatric Research Glossary

The scientific study of how drugs affect mood, sensation, thinking, and behavior in psychiatric conditions.

Referring to medications that affect the mind, emotions, and behavior, commonly studied in psychiatric research for ment...

A research study design where participants are randomly assigned to treatment groups, considered the gold standard for t...

A study outcome measure that has been accepted by regulatory agencies for drug approval decisions.

Predetermined checkpoint in drug development representing significant progress toward regulatory approval.

Therapeutic strategies and interventions designed to reduce the risk of symptom recurrence after treatment response or r...

Statistical analysis examining the proportion of patients achieving predefined improvement thresholds on clinical rating...

The pattern of symptom change over time during psychiatric treatment, often modeled statistically.

Adverse event that results in death, hospitalization, disability, or is life-threatening or medically significant.

Structured Clinical Interview for DSM-5 Disorders, a semi-structured diagnostic interview tool.

A potentially life-threatening condition caused by excessive serotonergic activity, often resulting from drug interactio...

A class of antidepressant medications that primarily work by blocking the reuptake of serotonin in the brain.

A determination that observed differences in psychiatric research results are unlikely due to chance alone, typically in...

Psychiatric symptoms that are present but do not meet the full diagnostic criteria for a specific disorder.

A broad term encompassing suicidal ideation, behaviors, and attempts, used as a safety endpoint in psychiatric trials.

The proportion of participants who transition from depression to mania/hypomania during treatment or study period.

A potentially irreversible movement disorder characterized by involuntary repetitive movements, typically caused by long...

An adverse event that emerges during treatment or worsens from baseline after treatment initiation.

Statistical method analyzing time until occurrence of specific clinical outcomes, accounting for censored data.

Patient compliance with prescribed medication regimens, measured through pill counts, plasma levels, or electronic monit...

Adverse events or symptoms that occur or worsen after treatment initiation, used to establish causal relationship with s...

An adverse event that occurs after the start of study treatment and was not present at baseline.

Manic or hypomanic episodes that develop during antidepressant treatment in individuals with bipolar disorder.

Referring to patients who have not previously received pharmacological treatment for their psychiatric condition.