Neuropathology Glossary

Chromosomal alteration involving loss of chromosome arms 1p and 19q, defining oligodendrogliomas.

A fulminant demyelinating disease characterized by widespread white matter necrosis and hemorrhage.

A protein that forms pathological aggregates in Parkinson's disease, dementia with Lewy bodies, and related synucleinopa...

Extracellular protein deposits composed primarily of amyloid beta peptide, a pathological hallmark of Alzheimer's diseas...

A rare WHO grade I cortical tumor characterized by glial cells arranged around blood vessels.

A type of brain tumor arising from astrocytes, classified by grade and commonly referenced in pathology reports.

Proliferation and activation of astrocytes in response to brain injury or disease.

Enlarged neurons with pale, swollen cytoplasm, characteristic of Pick's disease and related tauopathies.

Silver impregnation technique used to visualize neurofibrils, axons, and neuritic plaques in neuropathological examinati...

Neurons containing two nuclei, often indicating cellular stress, aging, or pathological conditions.

A neuropathological staging system for Alzheimer's disease based on the anatomical distribution of neurofibrillary tangl...

Neuronal response to axonal injury characterized by dissolution of Nissl substance and nuclear displacement.

A benign intraventricular tumor composed of uniform small round cells with neuronal differentiation.

Consortium to Establish a Registry for Alzheimer's Disease scoring system for neuritic plaques in dementia diagnosis.

Deposition of amyloid protein in brain blood vessel walls, associated with hemorrhage and cognitive decline.

Pathological dissolution of Nissl substance in neuronal cell bodies following injury or disease.

Neuron showing dissolution of Nissl bodies due to injury or stress, indicating cellular damage or metabolic disturbance.

Spherical, basophilic, PAS-positive structures found in normal aging brain and various neurological conditions.

Congenital absence of the corpus callosum due to failure of commissural fiber development during embryogenesis.

Dysplastic cortical lesions characteristic of tuberous sclerosis complex, featuring enlarged dysmorphic neurons and ball...

Abnormal protein aggregates within neuronal cell bodies that characterize various neurodegenerative diseases.

Formation of clear spaces within neuronal cytoplasm, indicating cellular stress or pathological processes.

A large demyelinating lesion that mimics a neoplasm clinically and radiologically.

A benign cortical tumor composed of oligodendroglia-like cells and neurons with a multinodular architecture.