Hematologic Oncology Glossary

First-line chemotherapy regimen for Hodgkin lymphoma combining four drugs. Standard treatment protocol.

A rapidly progressing cancer of the lymphoid blood cells, commonly abbreviated as ALL in medical documentation.

A rapidly progressing cancer of the blood and bone marrow characterized by the accumulation of abnormal white blood cell...

Monoclonal antibody targeting CD52 used in certain hematologic malignancies. Potent immunosuppressive agent.

A therapeutic procedure involving the transfer of hematopoietic stem cells from a genetically different donor to a recip...

Standard staging system for lymphomas using roman numerals I-IV. Fundamental classification for treatment planning.

Class of chemotherapy drugs derived from Streptomyces bacteria, including doxorubicin and daunorubicin.

A procedure using the patient's own stem cells to restore bone marrow function after high-dose chemotherapy.

A protein marker used for prognosis and staging in various hematologic malignancies.

A staging system for chronic lymphocytic leukemia based on the number of lymphoid areas involved and presence of anemia...

An immature hematopoietic cell characterized by large size, high nuclear-to-cytoplasmic ratio, and prominent nucleoli.

An acute transformation of chronic myeloid leukemia characterized by increased immature blood cells and resembling acute...

A bispecific T-cell engager (BiTE) antibody that redirects T cells to target CD19-positive B cells in acute lymphoblasti...

A diagnostic procedure involving extraction of bone marrow tissue to examine cellular composition and architecture for h...

An antibody-drug conjugate targeting CD30-positive lymphomas, particularly used in Hodgkin lymphoma treatment.

Interim treatment given while awaiting definitive therapy, commonly used before CAR-T cell therapy availability.

Lymphoma masses exceeding specific size criteria, typically 10 cm in diameter. Affects staging and treatment planning.

Highly aggressive B-cell lymphoma with characteristic MYC translocation. Requires intensive treatment protocols.

Immunotherapy using genetically modified T cells that express chimeric antigen receptors to target cancer cells.

A high-risk cytogenetic abnormality involving loss of the p53 tumor suppressor gene, associated with poor prognosis in C...

A malignancy characterized by the clonal proliferation and accumulation of mature-appearing B lymphocytes in blood, bone...

A slowly progressing blood cancer characterized by the presence of the BCR-ABL fusion gene, typically occurring in the c...

The acquisition of additional genetic abnormalities by malignant cell clones over time, leading to disease progression.

A comprehensive blood test that measures various blood components and provides detailed analysis of white blood cell typ...