Neuro Pathology Glossary

Glial cell positioned closely around a neuron, often indicating pathological change or response to injury.

Pathological clustering of glial cells around neurons, indicating neuronal injury or stress.

Clear space around the nucleus in neurons or other cells. May indicate artifact, viral infection, or specific pathologic...

Clear cytoplasmic space surrounding the nucleus in certain pathological conditions, often seen in oligodendrogliomas.

Accumulation of inflammatory cells around blood vessels in the central nervous system. A hallmark finding in various neu...

Inflammatory infiltrate of lymphocytes surrounding blood vessels in brain parenchyma, indicating neuroinflammation.

Characteristic histologic pattern where tumor cell processes radiate toward blood vessels, typical of ependymal tumors.

Radial arrangement of tumor cells around blood vessels forming a characteristic architectural pattern. Pathognomonic fea...

Fluid-filled spaces surrounding blood vessels in the brain, important in cerebrospinal fluid circulation and neuroinflam...

Spherical, argyrophilic cytoplasmic inclusion containing tau protein, characteristic of Pick's disease and frontotempora...

A benign, WHO grade I astrocytic tumor characterized by bipolar cells with long hair-like processes, commonly occurring...

Calcified, concentric lamellar structures commonly found in meningiomas and some other tumors.

Pattern of tumor cell arrangement around necrotic zones, forming a characteristic fence-like border in glioblastoma.

Proliferation and hypertrophy of glial cells in response to CNS injury or disease.

Eosinophilic, elongated cytoplasmic inclusion in astrocytes, characteristic of pilocytic astrocytomas and Alexander dise...

A rare WHO grade I tumor characterized by perivascular rosettes and neurocytic rosettes, typically occurring in young ad...

Clustering of glial cells around neurons, typically indicating neuronal injury or stress in neuropathological examinatio...

A benign nerve sheath tumor arising from Schwann cells, most commonly affecting cranial nerve VIII (acoustic neuroma).

Rapid intraoperative diagnostic technique involving crushing and spreading tissue on slides for immediate microscopic ex...

A slow-growing astrocytic tumor associated with tuberous sclerosis complex, characterized by large gemistocytic cells.

Pattern of tumor dissemination along the subependymal surface of ventricular walls, particularly in high-grade gliomas.

Reactive astrocytic proliferation beneath the pia mater, often indicating cortical injury or chronic pathological proces...

A microtubule-associated protein that forms pathological tangles in neurodegenerative diseases.

Enzyme component whose promoter mutations are significant molecular markers in CNS tumors. TERT promoter status helps cl...