Pediatric Hematology Glossary

An immature red blood cell precursor found in bone marrow that still contains a nucleus. Abnormal numbers or morphology...

Automated red blood cell exchange procedure used to treat sickle cell crises and prevent complications.

A group of inherited disorders affecting red blood cell metabolism, leading to hemolytic anemia in affected children.

A non-specific inflammatory marker measuring how quickly red blood cells settle in a test tube over one hour.

Elevated red blood cell mass or concentration above normal ranges, which may be primary, secondary, or relative in origi...

Hormone that stimulates red blood cell production, often used therapeutically in pediatric anemia.

Blood cell production occurring outside the bone marrow, typically in the liver and spleen.

X-linked bleeding disorder caused by deficient or dysfunctional coagulation factor IX, also known as hemophilia B.

A rare inherited bone marrow failure syndrome characterized by progressive pancytopenia, physical abnormalities, and inc...

Life-threatening condition combining fever with dangerously low white blood cell counts in cancer patients.

Fluorescence in situ hybridization, a molecular technique used to detect chromosomal abnormalities in hematologic malign...

Laboratory technique essential for diagnosing and classifying pediatric leukemias and lymphomas.

X-linked enzyme deficiency causing hemolytic anemia triggered by oxidative stress from certain foods, drugs, or infectio...

Immune-mediated complication following hematopoietic stem cell transplantation where donor immune cells attack recipient...

Minor adult hemoglobin variant elevated in beta-thalassemia trait, measured in hemoglobin analysis.

Intracellular precipitates of denatured hemoglobin visible with supravital staining. They indicate oxidative damage to r...

A glycosylated hemoglobin that serves as a marker for average blood glucose levels over 2-3 months in pediatric patients...

Abnormal hemoglobin composed of four gamma chains, indicating severe alpha-thalassemia and associated with hydrops fetal...

Hemoglobin variant that causes mild hemolytic anemia when homozygous and can compound sickle cell disease when heterozyg...

Laboratory test that separates different types of hemoglobin to diagnose hemoglobinopathies in children.

Fetal hemoglobin that protects against sickling and is a target for therapeutic intervention.

A form of alpha-thalassemia caused by the loss of three alpha-globin genes, resulting in moderate to severe anemia.

Abnormal hemoglobin variant causing sickle cell disease when present in homozygous form (HbSS).

A form of sickle cell disease where patients inherit one sickle cell gene and one hemoglobin C gene. Generally milder th...