Pediatric Immunology Glossary

Genetic disorder causing severe combined immunodeficiency due to toxic accumulation of purine metabolites in lymphocytes...

A substance added to vaccines to enhance the immune response, particularly important in pediatric vaccination schedules.

Genetic variants of immunoglobulin or other immune proteins that differ between individuals, relevant in pediatric trans...

Describing immune cells that are unresponsive to antigenic stimulation, often seen in immunocompromised pediatric patien...

The absence of an expected immune response to specific antigens, often tested via skin patch testing in pediatric patien...

A rare genetic disorder combining progressive neurodegeneration with immunodeficiency and increased cancer susceptibilit...

A disorder of lymphocyte apoptosis causing lymphadenopathy, splenomegaly, and autoimmune cytopenias.

A primary immunodeficiency characterized by absent or deficient MHC class I or II molecule expression on immune cells.

A therapeutic procedure involving infusion of hematopoietic stem cells to reconstitute the immune system in patients wit...

Abnormal widening and scarring of airways, often seen as a complication of recurrent respiratory infections in immunodef...

Cluster of differentiation antigens used to identify and classify immune cell types and developmental stages.

Primary immunodeficiency affecting phagocyte function, characterized by recurrent bacterial and fungal infections with g...

Inherited disorders affecting the complement system, leading to increased susceptibility to certain infections.

Preparative treatment protocol used before hematopoietic stem cell transplantation to suppress immunity and create space...

Common Variable Immunodeficiency, a primary immunodeficiency characterized by low antibody levels and recurrent infectio...

Excessive and uncontrolled release of pro-inflammatory cytokines that can cause severe tissue damage and organ dysfuncti...

A primary immunodeficiency disorder caused by chromosomal deletion affecting thymic development and T-cell production.

A flow-cytometry-based functional test that measures the oxidative burst of neutrophils by detecting conversion of dihyd...

The percentage of donor-derived cells in a transplant recipient, used to monitor engraftment success.

Inflammatory complication following hematopoietic stem cell transplantation characterized by fever, rash, and organ dysf...

Progressive immune recognition of additional antigenic determinants during autoimmune disease development in pediatric p...

A laboratory technique used to analyze cell populations by measuring physical and chemical characteristics of individual...

A genetic alteration that enhances or creates new protein activity, often causing immune dysregulation in pediatric pati...

A therapeutic approach involving introduction of genetic material to correct defective genes causing immunodeficiency di...