Pediatric Immunology Glossary

A complication of bone marrow transplantation where donor immune cells attack recipient tissues.

A small molecule that becomes immunogenic only when bound to a larger carrier protein, relevant in pediatric drug allerg...

Hematopoietic stem cell transplantation, a curative treatment for severe primary immunodeficiency disorders.

Primary immunodeficiency characterized by extremely elevated IgE levels, recurrent skin and lung infections, and distinc...

Abnormally low levels of gamma globulins (antibodies) in the blood, leading to increased susceptibility to infections.

A temporary condition of low immunoglobulin levels in infants, typically resolving as the child's immune system matures.

A genetic mutation that reduces but does not eliminate protein function, often causing milder immunodeficiency phenotype...

A primary immunodeficiency caused by mutations affecting interleukin-2 receptor components, impairing T-cell activation.

Molecular complexes formed by antibodies bound to antigens that can deposit in tissues and cause inflammatory damage in...

Abnormal immune system control leading to inappropriate responses such as autoimmunity or excessive inflammation in pedi...

A rare X-linked primary immunodeficiency caused by FOXP3 mutations, characterised by severe early-onset autoimmunity inc...

Group of primary immunodeficiencies characterized by autoimmunity, autoinflammation, and atopy due to defective immune r...

The recovery of immune function following treatment, particularly after bone marrow transplantation or gene therapy in i...

A paradoxical inflammatory response that occurs following immune system recovery in immunocompromised patients.

A condition characterised by deficient serum levels of one or more of the four IgG subclasses (IgG1–IgG4) despite normal...

Treatment involving administration of pooled human immunoglobulins to patients with antibody deficiencies.

Selective reduction in specific IgG subclasses while total IgG levels remain normal, causing recurrent infections in chi...

The process of restoring normal immune system function following treatment for primary immunodeficiency disorders.

The immune system's ability to rapidly recognize and respond to previously encountered antigens, fundamental to pediatri...

Flow cytometric analysis of immune cell surface markers to characterize and quantify lymphocyte populations.

Age-related decline in immune system function affecting both innate and adaptive immunity in pediatric patients with chr...

The current preferred term for primary immunodeficiencies, emphasizing their genetic basis and diverse manifestations.

A rare X-linked immunodeficiency characterized by immune dysregulation, polyendocrinopathy, enteropathy, and X-linked in...

Intravenous immunoglobulin therapy used to replace antibodies in patients with immunodeficiency disorders.