Head Neck Oncology Glossary
100 terms total — 24 showing — Last updated 15 Sep 2026
sentinel lymph node biopsy
Surgical technique to identify and remove the first lymph node draining a tumor site.
esthesioneuroblastoma
Rare malignant neuroectodermal tumor arising from the olfactory epithelium in the nasal cavity.
extracapsular extension
Tumor growth beyond the capsule of a lymph node, indicating aggressive disease.
fibula free flap
Vascularized bone graft from the fibula used for mandibular reconstruction in head and neck cancer surgery.
field cancerization
Molecular concept describing widespread mucosal changes in the upper aerodigestive tract from carcinogenic exposure. Exp...
first bite syndrome
Severe cramping pain in the parotid region with the first bite of each meal. Complication following surgery near the dee...
free flap reconstruction
Surgical technique using tissue transfer with microvascular anastomosis to reconstruct defects after tumor resection.
Frey syndrome
Abnormal sweating and flushing in the preauricular region during eating following parotidectomy. Results from aberrant n...
glossectomy
Surgical removal of part or all of the tongue to treat oral cavity malignancies.
hemilaryngectomy
Surgical removal of one half of the larynx while preserving voice and swallowing function.
hemimandibulectomy
Surgical removal of half of the mandible, typically performed for extensive mandibular tumors.
HPV-positive oropharyngeal cancer
Oropharyngeal squamous cell carcinoma associated with human papillomavirus infection, particularly HPV-16.
hyoid bone suspension
Surgical technique to elevate and secure the hyoid bone, often used in airway reconstruction.
hypoglossal nerve
Twelfth cranial nerve controlling tongue movement; injury causes tongue deviation and speech/swallowing difficulties.
IMRT
Advanced radiation therapy technique that modulates beam intensity to spare normal tissues while targeting tumors.
infraorbital nerve
Branch of the maxillary division of the trigeminal nerve, often at risk during maxillofacial oncology surgery.
internal jugular vein
Major cervical vein; sacrifice during radical neck dissection affects venous drainage and may cause complications.
Karnofsky Performance Scale
Functional status assessment tool using percentage scores (0-100%) to evaluate cancer patient activity levels. Alternati...
keratosis
Thickened, hyperkeratinized epithelial lesion that may represent premalignant change in head and neck mucosa.
laryngectomy
Surgical removal of the larynx, typically performed for advanced laryngeal cancer.
lymphangioma
Benign lymphatic malformation commonly occurring in the head and neck region, particularly in pediatric patients.
lymphoepithelial carcinoma
Undifferentiated nasopharyngeal carcinoma with prominent lymphoid infiltrate. Strongly associated with Epstein-Barr viru...
lymphoscintigraphy
Nuclear medicine imaging study to map lymphatic drainage patterns.
lymphovascular invasion
Tumor cell penetration into lymphatic or blood vessels, indicating increased metastatic potential.
marginal mandibular nerve
Branch of facial nerve controlling lower lip movement; injury causes asymmetric smile and lip incompetence.