Head Neck Oncology Glossary
100 terms total — 24 showing — Last updated 15 Sep 2026
sentinel lymph node biopsy
Surgical technique to identify and remove the first lymph node draining a tumor site.
marginal mandibulectomy
Surgical removal of the upper portion of the mandible while preserving the inferior border and continuity.
masticator space
Anatomical compartment containing muscles of mastication, frequently involved in head and neck cancer spread.
masticator space infection
Deep neck space infection involving muscles of mastication. Can cause trismus and requires urgent management due to pote...
maxillectomy
Surgical removal of part or all of the maxilla (upper jaw) to treat tumors of the maxillary sinus or palate.
microvascular free flap
Tissue transfer requiring microsurgical connection of blood vessels to restore circulation.
modified radical neck dissection
Surgical removal of neck lymph nodes while preserving one or more important structures.
mucosal melanoma
Rare melanoma arising from mucosal surfaces of the head and neck, distinct from cutaneous melanoma.
mucositis
Inflammatory reaction of mucous membranes commonly occurring during head and neck radiation therapy.
nasopharyngeal carcinoma
A malignant tumor arising from the epithelial lining of the nasopharynx, strongly associated with EBV infection.
nasoseptal flap
Pedicled flap from nasal septum used for skull base reconstruction after endoscopic tumor resection.
neck dissection
Surgical procedure to remove lymph nodes from the neck, classified by anatomical levels and structures preserved.
olfactory neuroblastoma
Rare malignant tumor arising from olfactory epithelium, also known as esthesioneuroblastoma.
osteoradionecrosis
Radiation-induced bone necrosis, most commonly affecting the mandible in head and neck cancer patients.
p16 immunostaining
Laboratory test used as a surrogate marker for HPV infection in head and neck cancers.
palatoplasty
Surgical reconstruction of the palate, often performed after oncological resection or for congenital defects.
panendoscopy
Comprehensive endoscopic examination of the upper aerodigestive tract including nasal cavity, oral cavity, pharynx, and...
paraganglioma
Neuroendocrine tumor arising from paraganglia in the head and neck. Most commonly occurs at carotid body, jugular forame...
parapharyngeal space
Deep fascial space lateral to the pharynx that serves as a conduit for tumor spread between the skull base and neck.
parotidectomy
Surgical removal of the parotid gland, typically performed for salivary gland tumors.
pectoralis major myocutaneous flap
Regional muscle and skin flap commonly used for reconstruction in head and neck surgery. Based on the pectoralis major m...
perineural invasion
Tumor spread along nerve pathways, an important histologic feature indicating aggressive disease behavior.
PET-CT
Hybrid imaging combining positron emission tomography with computed tomography for cancer staging and surveillance.
pharyngocutaneous fistula
Abnormal communication between pharynx and skin surface, commonly occurring after laryngectomy.
prevertebral fascia
Deep cervical fascial layer covering the prevertebral muscles and cervical vertebrae. Important anatomic landmark in ass...