Precision Oncology Glossary

High-throughput DNA sequencing technology enabling rapid analysis of multiple genes, exomes, or whole genomes simultaneo...

Next-generation sequencing technology used for comprehensive genomic analysis in cancer diagnosis.

A cancer cell's dependence on continued oncogene activity for survival and proliferation, creating therapeutic vulnerabi...

A metabolic compound that accumulates due to cancer-associated enzyme defects and contributes to tumorigenesis through e...

A numerical recurrence score derived from a multigene expression assay used to guide treatment decisions in breast cance...

Testing therapeutic agents on three-dimensional tumor models derived from patient samples to predict treatment response.

A targeted therapy that blocks PARP enzymes, preventing DNA repair in cancer cells with BRCA mutations.

A molecular diagnostic document detailing disrupted cellular pathways and corresponding therapeutic opportunities.

Treatment approach targeting specific molecular signaling cascades rather than individual gene mutations.

Quantitative measurement of programmed death-ligand 1 protein on tumor cells, used to predict immunotherapy response.

Programmed death-ligand 1, a protein biomarker used to predict immunotherapy response.

A measurable biological indicator that demonstrates a drug's effect on its target or downstream pathways, used to monito...

A document detailing how genetic variants affect drug metabolism, efficacy, and toxicity in cancer treatment.

A specific DNA repair gene alteration associated with hypermutated tumors and enhanced immunotherapy response.

A clinical document summarizing molecular findings and therapeutic recommendations based on tumor profiling.

An integrated system combining genomic testing, bioinformatics analysis, and clinical decision support tools to guide pe...

Standardized process integrating molecular testing, data analysis, and treatment selection for individualized cancer car...

A genetic alteration that enables cancer cells to survive and proliferate despite targeted therapy, leading to treatment...

A genetic alteration that occurs in non-reproductive cells during an individual's lifetime and is not inherited by offsp...

A genetic alteration affecting RNA splicing signals that can disrupt normal mRNA processing, potentially leading to aber...

A therapeutic strategy where combined inhibition of two genes or pathways is lethal to cancer cells but tolerable to nor...

Genetic variant with available FDA-approved or investigational therapies that specifically address the molecular abnorma...

A cellular signaling cascade with molecular components that can be effectively inhibited or modulated by approved or inv...

The development of insensitivity to cancer treatment, either present initially (primary resistance) or acquired during t...