Epilepsy Medicine Glossary
100 terms total — 24 showing — Last updated 15 Sep 2026
Functional hemispherectomy
A surgical procedure that disconnects one brain hemisphere while leaving most tissue in place. Used for severe hemispheric epilepsy.
Ictal SPECT
Single photon emission computed tomography performed during or immediately after a seizure to identify seizure onset zon...
Infantile spasms
A specific seizure type occurring in infancy, characterized by sudden flexion or extension movements, often occurring in...
Interictal
Occurring between seizures, during seizure-free periods.
Intractable epilepsy
Epilepsy that fails to respond adequately to appropriate antiseizure medication trials.
Juvenile myoclonic epilepsy
A genetic epilepsy syndrome beginning in adolescence, characterized by myoclonic jerks, generalized tonic-clonic seizure...
Ketogenic diet
A high-fat, low-carbohydrate medical diet used as a treatment for epilepsy, particularly in children with refractory sei...
Kindling
A phenomenon where repeated subthreshold electrical stimulation eventually produces seizures.
Lateralization
The process of determining whether seizure activity originates from the left or right hemisphere of the brain.
Lennox-Gastaut syndrome
A severe childhood epilepsy syndrome characterized by multiple seizure types, intellectual disability, and distinctive E...
Levetiracetam
A broad-spectrum antiepileptic drug with a unique mechanism of action through synaptic vesicle protein 2A binding.
Localization-related epilepsy
Epilepsy originating from a specific, identifiable brain region, also known as focal or partial epilepsy.
Magnetoencephalography
A non-invasive neuroimaging technique that measures magnetic fields generated by electrical brain activity.
Mesial temporal sclerosis
Neuronal loss and gliosis in the hippocampus, the most common pathological finding in temporal lobe epilepsy.
Myoclonic seizure
A type of seizure characterized by sudden, brief, shock-like muscle jerks that may involve the entire body or specific m...
Neuropsychological testing
Standardized assessment of cognitive functions including memory, language, and executive function. Essential component o...
Non-epileptic events
Paroxysmal episodes that resemble seizures but are not caused by abnormal electrical brain activity.
Periictal
The time period immediately surrounding a seizure, encompassing both preictal and postictal phases.
Pharmacokinetics
The study of how antiseizure medications are absorbed, distributed, metabolized, and eliminated by the body. Critical fo...
Pharmacoresistant epilepsy
Epilepsy that fails to become seizure-free despite adequate trials of two tolerated antiseizure medications.
Photoparoxysmal response
An abnormal EEG response to photic stimulation, indicating increased photosensitivity and seizure risk.
PNES
Psychogenic non-epileptic seizures - episodes that resemble epileptic seizures but lack epileptic brain activity.
Polypharmacy
The use of multiple antiseizure medications simultaneously in epilepsy treatment. Associated with increased risk of drug...
Polyspike complexes
EEG pattern characterized by multiple sharp waves followed by slow waves, often associated with myoclonic seizures.
Polytherapy
Treatment approach using multiple antiepileptic medications simultaneously to control seizures.