Hematologic Oncology Glossary

The absence of detectable disease below conventional morphologic thresholds, indicating deep remission.

A cancer of plasma cells that typically involves the bone marrow and is characterized by the production of abnormal prot...

High-dose chemotherapy and/or radiation therapy given before stem cell transplantation to eradicate malignant cells and...

A group of clonal hematopoietic disorders characterized by dysplastic changes in bone marrow cells and peripheral blood...

A myeloproliferative neoplasm characterized by bone marrow fibrosis, extramedullary hematopoiesis, and progressive bone...

A condition characterized by an abnormally low number of neutrophils in the peripheral blood.

A heterogeneous group of lymphoid malignancies that do not contain Reed-Sternberg cells and typically spread in a random...

A hematologic condition characterized by reduction in all three major blood cell lines: red blood cells, white blood cel...

Manual microscopic examination of blood cells to assess morphology, distribution, and identify abnormal findings.

A specific chromosomal abnormality found in chronic myeloid leukemia and some acute lymphoblastic leukemia cases.

An abnormal increase in plasma cells in the bone marrow or other tissues.

A myeloproliferative neoplasm characterized by excessive production of red blood cells, typically associated with JAK2 m...

Clinical endpoint measuring time from treatment start until disease progression or death, whichever occurs first.

Standard chemotherapy regimen combining rituximab with CHOP for treating B-cell lymphomas. Cornerstone treatment protoco...

Prognostic staging system for chronic lymphocytic leukemia using risk categories. Standard classification tool.

Diagnostic malignant cell characteristic of classical Hodgkin lymphoma. Essential pathologic feature for diagnosis.

Hematologic malignancy that has returned after initial treatment response or failed to respond to standard therapy.

The absence or significant reduction of cancer signs and symptoms, classified as complete or partial based on specific c...

A measure of immature red blood cells, indicating bone marrow's red cell production activity.

The transformation of chronic lymphocytic leukemia into an aggressive large cell lymphoma.

The transformation of chronic lymphocytic leukemia into a more aggressive lymphoma, typically diffuse large B-cell lymph...

Treatment approach for patients with refractory or relapsed disease after failure of standard therapies.

Enlarged spleen commonly seen in hematologic malignancies. Important clinical finding requiring assessment.

A condition characterized by an abnormally low platelet count in the peripheral blood, typically below 150,000 per micro...