Pediatric Oncology Glossary

Hearing loss or vestibular dysfunction caused by chemotherapy agents, particularly platinum compounds and aminoglycoside...

Posterior cranial fossa syndrome, a neurological complication following brain tumor surgery in children.

Standardized measure of a patient's functional ability and overall condition, important for treatment decisions.

An abnormal chromosome resulting from translocation t(9;22) that creates the BCR-ABL fusion gene, associated with certai...

A WHO Grade I brain tumor representing the most common primary brain tumor in children, characterized by slow growth and...

Describing cells or tissues that show variation in size, shape, and appearance, often indicating malignancy.

Primitive neuroectodermal tumor, a group of aggressive brain tumors affecting children and young adults.

Pediatric Oncology Discipline Committee, a regulatory advisory group for pediatric cancer drug development.

Persistent pulmonary hypertension of the newborn, a complication that can occur with certain pediatric cancer treatments...

A staging system for pediatric liver tumors based on the number of liver segments involved and vascular relationships.

Any departure from the approved study protocol that may affect patient safety or data integrity.

Large abnormal lymphoid cells with distinctive morphology that are pathognomonic for classical Hodgkin lymphoma.

Cancer that does not respond to initial treatment or shows resistance to standard therapeutic approaches.

The most common primary intraocular malignancy in children, arising from neural retinal cells and often presenting with...

A rare, aggressive malignant tumor characterized by loss of SMARCB1/INI1 expression, occurring predominantly in infants...

A soft tissue sarcoma arising from skeletal muscle cells, representing the most common soft tissue tumor in children.

Treatment given after initial therapy has failed, designed to achieve remission in relapsed or refractory disease.

Anatomical location where chemotherapy penetration is limited, allowing cancer cells to survive and potentially relapse.

Supportive tissue component in neuroblastoma tumors derived from Schwann cells, indicating differentiation.

Histologic feature of neuroblastoma characterized by cells with abundant cytoplasm and peripheral chromatin.

International Society of Paediatric Oncology, a global organization that develops treatment protocols for childhood canc...

European cooperative group conducting neuroblastoma clinical trials and research protocols.

A metabolic emergency caused by rapid destruction of tumor cells releasing intracellular contents into circulation.

Biochemical substances measurable in blood or other body fluids that can indicate the presence or progression of certain...