Psychopharmacology Glossary

The pattern of cognitive impairments or enhancements associated with a specific psychotropic medication or drug class.

The phenomenon where tolerance to one substance reduces sensitivity to pharmacologically similar substances.

Increased production of cytochrome P450 enzymes, leading to enhanced drug metabolism.

A family of liver enzymes responsible for metabolizing most psychiatric medications.

The process by which certain drugs block the enzymatic activity of CYP450 enzymes, potentially altering the metabolism o...

A long-acting formulation of medication given by injection that provides sustained drug release over weeks or months.

A cluster of symptoms that occur when psychiatric medications are stopped abruptly or reduced too quickly.

Relating to or affecting dopamine neurotransmitter pathways in the brain.

The correlation between drug dose and the magnitude of therapeutic or adverse effects.

Decreased responsiveness to a drug following repeated administration, requiring higher doses for the same effect.

When one medication affects the activity of another when taken concurrently.

Manic episode triggered by medications, particularly antidepressants, stimulants, or corticosteroids, in susceptible ind...

Duration of Untreated Psychosis - the time period between onset of psychotic symptoms and initiation of adequate antipsy...

Involuntary muscle contractions causing abnormal postures or repetitive movements, often occurring as an adverse effect...

Movement disorders caused by medications that affect dopamine pathways, including tremor, rigidity, and abnormal movemen...

Older antipsychotic medications that primarily block dopamine receptors, also known as typical or conventional antipsych...

Initial metabolism of an orally administered drug by the liver before reaching systemic circulation.

Relating to or affecting gamma-aminobutyric acid neurotransmitter systems.

The time required for the concentration of a drug in the body to reduce by half through metabolism and elimination.

Elevated serum prolactin levels, commonly caused by dopamine-blocking antipsychotic medications.

A drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that of the agon...

Neurobiological phenomenon where repeated subthreshold stimuli eventually trigger full seizures or mood episodes.

Potentially serious skin reaction associated with lamotrigine therapy that can progress to life-threatening conditions l...

Dangerous elevation of lithium blood levels causing neurological, gastrointestinal, and renal symptoms that can be life-...