Neuropathology Glossary

A neuronal migration disorder characterized by clusters of ectopic neurons lining the lateral ventricles due to failed r...

Tau-containing cytoplasmic inclusions characteristic of Pick's disease and frontotemporal dementia.

A WHO grade I astrocytic tumor characterized by bipolar cells with long hair-like processes.

Concentric calcified structures found in certain brain tumors, particularly meningiomas.

Selective neuronal loss in specific cortical layers following hypoxic-ischemic injury, creating false laminar patterns.

Arrangement of elongated cell nuclei around areas of necrosis, characteristic of glioblastoma.

Activated astrocytic cell showing morphological and molecular changes in response to CNS injury or disease.

A pathological response involving proliferation and hypertrophy of glial cells following brain injury or disease.

Eosinophilic cytoplasmic inclusions in astrocytes, characteristic of pilocytic astrocytomas and Alexander disease.

Clustering of glial cells around neurons, typically indicating neuronal injury or disease.

Benign nerve sheath tumor arising from Schwann cells, most commonly affecting cranial and peripheral nerves.

Synaptosomal-associated protein of 25 kDa, used as a presynaptic marker in neuropathological studies.

Characteristic vacuolar degeneration of neuropil creating a sponge-like appearance in prion diseases.

Pattern of tissue damage creating a sponge-like appearance due to vacuole formation in neuropil.

Severe vacuolar degeneration of neuropil creating a sponge-like appearance, typically seen in prion diseases.

Spinal cord pathology involving both posterior columns and lateral corticospinal tracts, typically associated with vitam...

A progressive demyelinating disease caused by persistent measles virus infection of the CNS.

Progressive white matter disease caused by chronic small vessel disease, also known as Binswanger disease.

A WHO grade I tumor arising from subependymal nodules, typically associated with tuberous sclerosis.

Reactive astrocytic proliferation immediately beneath the pial surface of the brain, often indicating cortical injury.

A microtubule-associated protein that forms pathological tangles in Alzheimer's disease and related neurodegenerative di...

TAR DNA-binding protein 43, a pathological protein aggregate found in frontotemporal dementia and ALS.

Distinctive striped appearance of neurons caused by prominent Nissl substance, often accentuated in certain pathological...

Fusiform axonal swellings in Purkinje cell axons, characteristic of cerebellar pathology.