Neuro Oncology Glossary

Brain tissue swelling surrounding a tumor, appearing as hyperintense signal on T2-weighted MRI sequences and indicating...

Contrast uptake in brain tissue immediately surrounding a tumor on MRI, indicating blood-brain barrier disruption.

A WHO grade I benign brain tumor most commonly occurring in children, characterized by its circumscribed growth and exce...

Tumor arising in or near the pineal gland area, including germinomas, pinealocytomas, and other rare entities.

A clinical trial endpoint measuring time from treatment start to disease progression or death, requiring precise statist...

Characteristic microscopic pattern of cellular arrangement around necrotic areas, particularly seen in glioblastomas.

Treatment-related imaging changes that mimic tumor progression but represent therapy response, crucial for accurate tria...

Radiation-induced tissue death that can mimic tumor recurrence on imaging, requiring careful diagnostic distinction.

Standardized response assessment guidelines for neuro-oncology trials, essential for consistent editorial treatment of e...

A precise radiation therapy technique delivering high-dose radiation to small brain targets in a single session, commonl...

The standard treatment regimen for newly diagnosed glioblastoma combining radiation therapy with temozolomide.

A WHO Grade I tumor that occurs almost exclusively in patients with tuberous sclerosis complex, typically arising near t...

Tumor extension along the subependymal layer beneath the ventricular lining, characteristic of certain gliomas.

An aggressive embryonal brain tumor occurring above the tentorium cerebelli, now classified as CNS embryonal tumor NOS i...

An oral alkylating chemotherapy agent that is standard-of-care for glioblastoma treatment.

A genetic alteration in the telomerase reverse transcriptase promoter region, commonly found in gliomas and associated w...

Imaging technique that reconstructs white matter fiber pathways in the brain using diffusion tensor imaging data.

Numerical classification system that indicates the aggressiveness and malignant potential of brain tumors.

Genes that normally prevent uncontrolled cell growth; their loss of function contributes to brain tumor development.

A novel therapeutic modality using alternating electric fields to disrupt cancer cell division, requiring careful explan...

Electromagnetic field treatment modality that disrupts cancer cell division through alternating electric fields.

Seizures directly caused by brain tumors, requiring integrated neuro-oncological and epileptological management.

Brain swelling caused by increased vascular permeability, commonly seen around brain tumors on MRI.

Tumor extension into or contact with the brain's ventricular system, affecting cerebrospinal fluid flow.